The 5-HT2 antagonist ritanserin blocks dopamine re-uptake in the rat frontal cortex
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چکیده
منابع مشابه
The effect of ritanserin, a 5-HT2 receptor antagonist, on ischemic cerebral blood flow and infarct volume in rat middle cerebral artery occlusion.
BACKGROUND AND PURPOSE In a previous study from our laboratory, ritanserin, a specific 5-HT2 serotonin receptor antagonist, reduced ischemic damage in the setting of transient global ischemia. In this study, we examined the effect of ritanserin on ischemic cerebral blood flow, systemic blood pressure, and infarct volume in the model of permanent focal ischemia with brain temperature controlled ...
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One of the most important factors in drug addiction is stress. It has been shown that animals with prenatal stress history are more risky for drug dependence. It have also been shown that frontal cortex play a role in drug dependence. In the present study the effects of two kinds of mild stress during pregnancy on the development of frontal cortex in Wistar rats (250-300 g) were investigated. F...
متن کاملUncontrolled stress produces severe defect in development of frontal cortex in the rat
One of the most important factors in drug addiction is stress. It has been shown that animals with prenatal stress history are more risky for drug dependence. It have also been shown that frontal cortex play a role in drug dependence. In the present study the effects of two kinds of mild stress during pregnancy on the development of frontal cortex in Wistar rats (250-300 g) were investigated. F...
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Using extracellular recording we studied changes in the reactivity of rat frontal cortical slices to the 5-HT1A, 5-HT2 and 5-HT4 receptor agonists, (±)-2dipropyloamino-8-hydroxy-1,2,3,4-tetrahydronaphtalene hydrobromide (8-OHDPAT), (±)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) and zacopride, respectively, induced by an earlier treatment of animals with corticosterone lasting 1 or 3 we...
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Curcumin exhibits both cancer- preventive activity and growth inhibitory effects on several neoplastic cells including human colon cancer. Serotonin and its receptors have also been implicated in tumor development. This study investigated the effect of ritanserin, a selective serotonin 5HT2A receptor antagonist, alone and in combination with curcumin on colorectal cancer cell lines. Result...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2000
ISSN: 1359-4184,1476-5578
DOI: 10.1038/sj.mp.4000804